Glioma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms (rs3213801 and rs5744533) of DNA polymerase kappa gene are not related with glioma risk and prognosis: A case-control study.
|
31595696 |
2019 |
Congenital chromosomal disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Effects of DNA polymerase kappa and mismatch repair on dose-responses of chromosome aberrations induced by three oxidative genotoxins in human cells.
|
31294882 |
2020 |
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of human DNA polymerase kappa (hpol κ) in glioblastoma is associated with shorter survival time and resistance to the alkylating agent temozolomide (TMZ), making it an attractive target for the development of small-molecule inhibitors.
|
31082191 |
2019 |
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of human DNA polymerase kappa (hpol κ) in glioblastoma is associated with shorter survival time and resistance to the alkylating agent temozolomide (TMZ), making it an attractive target for the development of small-molecule inhibitors.
|
31082191 |
2019 |
Childhood Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of human DNA polymerase kappa (hpol κ) in glioblastoma is associated with shorter survival time and resistance to the alkylating agent temozolomide (TMZ), making it an attractive target for the development of small-molecule inhibitors.
|
31082191 |
2019 |
Glioblastoma Multiforme
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of human DNA polymerase kappa (hpol κ) in glioblastoma is associated with shorter survival time and resistance to the alkylating agent temozolomide (TMZ), making it an attractive target for the development of small-molecule inhibitors.
|
31082191 |
2019 |
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The results indicate that Polκ does not suppress BP-induced mutagenesis and carcinogenesis in the colon, but counteracts inflammation-induced mutagenesis in multiple organs..
|
30620413 |
2019 |
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Coronary Artery Disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
Hepatitis B
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that DNA polymerase κ (POLK), a Y-family DNA polymerase with maximum activity in non-dividing cells, substantially contributes to cccDNA formation during de novo HBV infection.
|
27783675 |
2016 |
Malignant neoplasm of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association Between Single Nucleotide Polymorphisms in DNA Polymerase Kappa Gene and Breast Cancer Risk in Chinese Han Population: A STROBE-Compliant Observational Study.
|
26765445 |
2016 |
Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association Between Single Nucleotide Polymorphisms in DNA Polymerase Kappa Gene and Breast Cancer Risk in Chinese Han Population: A STROBE-Compliant Observational Study.
|
26765445 |
2016 |
Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells.
|
26651356 |
2016 |
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells.
|
26651356 |
2016 |
Childhood Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells.
|
26651356 |
2016 |
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells.
|
26651356 |
2016 |
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
|
26414677 |
2015 |
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
Other 5p genes identified as targets of CNI play a role in DNA repair and cell cycle regulation (BASP1, TARS, PAIP1, BRD9, RAD1, SKP2, and POLS), signal transduction (OSMR), and mitochondrial oxidative phosphorylation (NNT, SDHA, and NDUFS6), suggesting that disruption of pathways involving these genes may contribute to CC progression.
|
18559093 |
2008 |
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Other 5p genes identified as targets of CNI play a role in DNA repair and cell cycle regulation (BASP1, TARS, PAIP1, BRD9, RAD1, SKP2, and POLS), signal transduction (OSMR), and mitochondrial oxidative phosphorylation (NNT, SDHA, and NDUFS6), suggesting that disruption of pathways involving these genes may contribute to CC progression.
|
18559093 |
2008 |
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Other 5p genes identified as targets of CNI play a role in DNA repair and cell cycle regulation (BASP1, TARS, PAIP1, BRD9, RAD1, SKP2, and POLS), signal transduction (OSMR), and mitochondrial oxidative phosphorylation (NNT, SDHA, and NDUFS6), suggesting that disruption of pathways involving these genes may contribute to CC progression.
|
18559093 |
2008 |
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase kappa in colorectal cancer.
|
17099721 |
2007 |
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase kappa in colorectal cancer.
|
17099721 |
2007 |
Malignant neoplasm of lung
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We report here that the overexpression of human DNA polymerase kappa, an error-prone enzyme that is up-regulated in lung cancers, induces DNA breaks and stimulates DNA exchanges as well as aneuploidy.
|
15665310 |
2005 |
Carcinogenesis
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Up-regulation of the error-prone DNA polymerase {kappa} promotes pleiotropic genetic alterations and tumorigenesis.
|
15665310 |
2005 |